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Immune & inflammation research

Conceptual illustration for Immune & inflammation

Host defense, immune signaling, and inflammation.

This topic groups related research questions. Shared biology does not make different peptides interchangeable, or establish a clinical benefit. Compare each paper’s population, preparation, and measured outcome.

ARA-290

ARA-290, also called cibinetide, is an erythropoietin-derived peptide investigated in tissue-protection research. A small clinical pilot examined neuropathy symptoms in people with sarcoidosis.

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Cortistatin

Cortistatin is a neuropeptide family investigated in inflammatory signaling. The selected study used a mouse arthritis model rather than people with rheumatoid arthritis.

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Enfuvirtide

Enfuvirtide is an HIV fusion inhibitor with historical combination-treatment evidence. MedlinePlus reports that the injection has been discontinued in the United States.

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KPV

KPV is a three-amino-acid peptide investigated in intestinal and immune-cell research. Its short sequence does not make clinical efficacy self-evident.

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LL-37

LL-37 is a human host-defense peptide investigated in wound biology. The selected clinical study tested topical treatment in a defined ulcer population.

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Peptide bioregulators (Khavinson peptides)

Peptide bioregulators are very short synthetic peptides, two to four amino acids long, developed by Vladimir Khavinson and colleagues in St. Petersburg. Each is named for the tissue it was proposed to support. Almost all published research on them comes from that group and its collaborators.

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Thymalin

Thymalin is a thymus-derived extract or peptide mixture. An older clinical report described long-term outcomes in elderly participants, but the abstract does not establish the methods needed for a firm causal longevity claim.

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Thymopentin

Thymopentin is a synthetic pentapeptide studied as an immunomodulator. A small 1985 randomized trial examined active rheumatoid arthritis.

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Thymosin alpha-1

Thymosin alpha-1, also called thymalfasin, is investigated for immune-related effects. The clinical value of immune modulation depends on the disease and endpoint.

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Thymulin

Thymulin is a thymic peptide whose biological activity depends on zinc. The featured human study examined zinc status and thymulin activity; it was not a trial of thymulin injections.

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VIP

Vasoactive intestinal peptide participates in vascular and immune signaling. A large trial of intravenous aviptadil in COVID-19 respiratory failure did not show a significant improvement in its primary outcome.

Research topics

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