Peps
What is Cortistatin?
Cortistatin is a neuropeptide family investigated in inflammatory signaling. The selected study used a mouse arthritis model rather than people with rheumatoid arthritis.
Biological role or research focus
Inflammatory arthritis models.
These findings do not establish reduced human joint damage or a clinically effective rheumatoid-arthritis treatment.
Role reference: Therapeutic effect of cortistatin on experimental arthritis by downregulating inflammatory and Th1 responses. · 2007 ↗
Names you may encounter
CST peptide
Search terms can include brands, combinations, or historical names. They are not automatic product equivalents.
- Class / identity
- Somatostatin-related neuropeptide family
- Research focus
- Inflammatory arthritis models
- Featured evidence
- Animal study
- Source check
- October 4, 2026
Biology & proposed mechanism
The investigators examined immune responses involving somatostatin- and ghrelin-receptor pathways. Experimental pathway effects do not establish clinical disease control.
Research context & identity
This profile covers a collagen-induced arthritis model and distinguishes laboratory immunology from a validated arthritis medicine.
What does the evidence show?
Selected published evidence, with the population, findings, and limits kept together. These original summaries draw on publication abstracts; they are not a systematic review.
Animal study · 2007
Cortistatin in collagen-induced arthritis
What did this publication test, and what did it find?
- Population / model
- DBA/1J mice with collagen-induced arthritis.
- Study design
- Animal intervention with clinical, tissue, and inflammatory immune-response measurements.
- Main finding
- The report described improved arthritis measures and reduced inflammatory responses, including changes in the Th1 response.
- Limits & context
- These findings do not establish reduced human joint damage or a clinically effective rheumatoid-arthritis treatment.
Read the original paper for methods, adverse events, funding, and conflicts of interest. Publisher access may require a subscription.
Further reading · 4 additional publication links
Exact-name PubMed search checked 2026-10-04. These records have not been appraised. A name match can include related compounds, combinations, or other formulations; it does not establish safety or benefit.
Structure, function and pharmacology of human itch GPCRs. ↗
Nature · 2021 Dec · Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
Read available full text ↗
Multi‑layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β‑catenin signaling activation (Review). ↗
International journal of molecular medicine · 2018 Aug · Journal Article, Review
Read available full text ↗
Somatostatin receptors. ↗
Biochimica et biophysica acta · 2003 Sep 22 · Journal Article, Review
Cortistatin exerts an immunomodulatory and neuroprotective role in a preclinical model of ischemic stroke. ↗
Pharmacological research · 2024 Dec · Journal Article
New editorial updates
New source discoveries
Links appear automatically. Unreviewed discoveries are not verified medical findings.
Safety & precautions
Safety & what remains unknown
A mouse inflammation model cannot determine human infection risk, endocrine effects, or long-term safety.
Evidence boundaries
These findings do not establish reduced human joint damage or a clinically effective rheumatoid-arthritis treatment.
This is not a complete list of contraindications, interactions, or adverse effects. Medicine labels apply to specific products and indications; research-use listings are not interchangeable with approved medicines.
What are people discussing?
No editorial transcript note has been reviewed for this profile yet. Below are the matching video records available for exploration; title and caption matches are not verified claims.
Watch the source discussions
0 matching video records · 0 with captions indexed.
Across the full library, 30 caption files are indexed from 20,199 inventoried videos. Most transcripts remain unreviewed. Select a thumbnail or timestamp to watch inside PepsRadar. Thumbnail images load from YouTube.
No matching video has been identified in the current snapshot.
Sources & supplier listings
Listings are grouped by the vendor’s stated identity. Blends and modified derivatives are labeled separately. Inclusion is not a quality assessment or an endorsement.
We have not added a supplier for this profile. Missing products and coded listings are not filled with guesses.
Catalog checked 2026-10-04. Seller listings retain their stated intended use. Shops covered: BioLongevity Labs, BioLongevity Supplements, American Peptides, PSPeptides. This is not a market-wide comparison. Affiliate participation does not determine evidence or editorial coverage.
Questions worth asking
- Is this evidence from a human rheumatoid-arthritis trial?
- What material, population, and route were actually studied?
- These findings do not establish reduced human joint damage or a clinically effective rheumatoid-arthritis treatment.
- What adverse effects, uncertainty, and conflicts of interest does the original source report?
Frequently asked questions
Is this evidence from a human rheumatoid-arthritis trial?
No. The featured evidence comes from an induced mouse arthritis model.
Does the publication verify a supplier’s product?
No. The tested material and a commercial listing need separate identity and batch checks. A research-use disclaimer does not establish clinical suitability.
References & editorial record
Source notes checked 2026-10-04. Original PepsRadar summaries. Not reviewed by a medical professional. Topic grouping is editorial navigation, not a treatment recommendation. Video notes specify which excerpts were reviewed; no full transcripts are published.