Peps
What is IGF-1 DES?
Des(1-3) IGF-1 is an IGF-1 analogue missing its first three amino acids. The featured study examined developing rat neural tissue in culture, rather than athletic performance.
Biological role or research focus
IGF signaling in laboratory tissue models.
These tissue-culture findings do not demonstrate muscle growth, strength, or safe use in people.
Role reference: Des (1-3) IGF-I potently enhances differentiated cell growth in olfactory bulb organ culture. · 1994 ↗
Names you may encounter
Des(1-3) IGF-1 · DES IGF-1
Search terms can include brands, combinations, or historical names. They are not automatic product equivalents.
- Class / identity
- IGF-1 analogue lacking its first three amino acids
- Research focus
- IGF signaling in laboratory tissue models
- Featured evidence
- Animal tissue study
- Source check
- October 4, 2026
Biology & proposed mechanism
The experiment compared growth-factor responses and cellular markers in an organ-culture model. Laboratory potency does not establish a superior clinical treatment.
Research context & identity
This page distinguishes the DES analogue from native IGF-1 and IGF-1 LR3. Findings should follow the exact analogue and tissue setting.
What does the evidence show?
Selected published evidence, with the population, findings, and limits kept together. These original summaries draw on publication abstracts; they are not a systematic review.
Animal tissue study · 1994
Des(1-3) IGF-1 in olfactory-bulb cultures
What did this publication test, and what did it find?
- Population / model
- Olfactory-bulb organ cultures from newborn rats.
- Study design
- Laboratory evaluation of des(1-3) IGF-1 and other growth-factor conditions using cellular and neuronal-marker measures.
- Main finding
- The publication reported changes in cellular uptake, morphology, and neuronal markers, with stronger activity for the DES analogue on selected readouts.
- Limits & context
- These tissue-culture findings do not demonstrate muscle growth, strength, or safe use in people.
Read the original paper for methods, adverse events, funding, and conflicts of interest. Publisher access may require a subscription.
Further reading · 4 additional publication links
Exact-name PubMed search checked 2026-10-04. These records have not been appraised. A name match can include related compounds, combinations, or other formulations; it does not establish safety or benefit.
The effects of insulin-like growth factor (IGF)-1, IGF-2, and des-IGF-1 on neuronal loss after hypoxic-ischemic brain injury in adult rats: evidence for a role for IGF binding proteins. ↗
Endocrinology · 1996 Mar · Journal Article, Research Support, Non-U.S. Gov't
Enforced epithelial expression of IGF-1 causes hyperplastic prostate growth while negative selection is requisite for spontaneous metastogenesis. ↗
Oncogene · 2008 May 1 · Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
IGF-I has a dual effect on insulin release from isolated, perifused adult rat islets of Langerhans. ↗
The Journal of endocrinology · 1997 Apr · Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
A key functional role for the insulin-like growth factor 1 N-terminal pentapeptide. ↗
The Biochemical journal · 1989 May 1 · Journal Article, Research Support, Non-U.S. Gov't
Read available full text ↗
New editorial updates
New source discoveries
Links appear automatically. Unreviewed discoveries are not verified medical findings.
Safety & precautions
Safety & what remains unknown
Growth-factor activity in a culture system cannot determine systemic glucose, tissue-growth, or long-term safety effects.
Evidence boundaries
These tissue-culture findings do not demonstrate muscle growth, strength, or safe use in people.
This is not a complete list of contraindications, interactions, or adverse effects. Medicine labels apply to specific products and indications; research-use listings are not interchangeable with approved medicines.
What are people discussing?
No editorial transcript note has been reviewed for this profile yet. Below are the matching video records available for exploration; title and caption matches are not verified claims.
Watch the source discussions
0 matching video records · 0 with captions indexed.
Across the full library, 30 caption files are indexed from 20,199 inventoried videos. Most transcripts remain unreviewed. Select a thumbnail or timestamp to watch inside PepsRadar. Thumbnail images load from YouTube.
No matching video has been identified in the current snapshot.
Sources & supplier listings
Listings are grouped by the vendor’s stated identity. Blends and modified derivatives are labeled separately. Inclusion is not a quality assessment or an endorsement.
We have not added a supplier for this profile. Missing products and coded listings are not filled with guesses.
Catalog checked 2026-10-04. Seller listings retain their stated intended use. Shops covered: BioLongevity Labs, BioLongevity Supplements, American Peptides, PSPeptides. This is not a market-wide comparison. Affiliate participation does not determine evidence or editorial coverage.
Questions worth asking
- Can laboratory potency be used to promise greater muscle growth?
- What material, population, and route were actually studied?
- These tissue-culture findings do not demonstrate muscle growth, strength, or safe use in people.
- What adverse effects, uncertainty, and conflicts of interest does the original source report?
Frequently asked questions
Can laboratory potency be used to promise greater muscle growth?
No. Potency on one cell or tissue readout is not a clinical performance outcome.
Does the publication verify a supplier’s product?
No. The tested material and a commercial listing need separate identity and batch checks. A research-use disclaimer does not establish clinical suitability.
References & editorial record
Source notes checked 2026-10-04. Original PepsRadar summaries. Not reviewed by a medical professional. Topic grouping is editorial navigation, not a treatment recommendation. Video notes specify which excerpts were reviewed; no full transcripts are published.