Peptide bioregulators (Khavinson peptides)

What is Peptide bioregulators (Khavinson peptides)?

Peptide bioregulators are very short synthetic peptides, two to four amino acids long, developed by Vladimir Khavinson and colleagues in St. Petersburg. Each is named for the tissue it was proposed to support. Almost all published research on them comes from that group and its collaborators.

Biological role or research focus

Gene-expression and aging research, mostly from one research group.

The evidence is concentrated in one research network, much of it in Russian-language journals, with few independent replications and few controlled human trials. A narrative review by the originating group is not a systematic review, and seller product names may not match the exact compounds studied.

Role reference: Peptide Regulation of Cell Differentiation · 2020 ↗

Names you may encounter

Khavinson peptides · Short peptide bioregulators · Bronchogen · Cardiogen · Cartalax · Chonluten · Cortagen · Livagen · Ovagen · Pancragen · Prostamax · Testagen · Thymogen · Thymagen · Vesilute · Vesugen · Vilon

Search terms can include brands, combinations, or historical names. They are not automatic product equivalents.

Class / identity

Family of synthetic two- to four-amino-acid peptides developed at the St. Petersburg Institute of Bioregulation and Gerontology

Research focus

Gene-expression and aging research, mostly from one research group

Featured evidence

Review by the originating research group

Source check

October 4, 2026

Source: Peptide Regulation of Cell Differentiation · 2020 ↗

Biology & proposed mechanism

The group proposes that these short peptides enter cells and nuclei and influence gene activity, including genes for cell differentiation, partly by interacting with DNA and histones. Their 2020 review summarizes cell, tissue and animal work; for example, it reports that AEDL (Bronchogen) and KEDW (Pancragen) promoted lung and pancreatic cell differentiation. These mechanisms come mainly from laboratory models and have rarely been tested independently.

Source: Peptide Regulation of Cell Differentiation · 2020 ↗

Research context & identity

This profile groups the members of the family that sellers list, because separate pages would mostly repeat the same small evidence base. Epitalon, Pinealon and Thymalin have their own profiles.

Sequences stated in published abstracts: Bronchogen (Ala-Glu-Asp-Leu, studied in lung and bronchial tissue), Cortagen (Ala-Glu-Asp-Pro), Livagen (Lys-Glu-Asp-Ala, liver), Pancragen (Lys-Glu-Asp-Trp, pancreas), Testagen (Lys-Glu-Asp-Gly) and Vilon (Lys-Glu). Cardiogen, Chonluten, Prostamax, Thymogen (sold as Thymagen) and Vesugen appear in the literature, but the abstracts checked did not state their sequences. Cartalax and Vesilute had no indexed publications. In PubMed, "Ovagen" refers to an unrelated veterinary follicle-stimulating hormone product, so a seller's "Ovagen peptide" could not be matched to any study.

Source: Peptide Regulation of Cell Differentiation · 2020 ↗

What does the evidence show?

Selected published evidence, with the population, findings, and limits kept together. These original summaries draw on publication abstracts; they are not a systematic review.

Read the original paper for methods, adverse events, funding, and conflicts of interest. Publisher access may require a subscription.

New editorial updates

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Safety & precautions

Safety & what remains unknown

Formal human safety data are limited. Small Russian clinical reports exist for some members, but they do not establish safety to modern trial standards, and research-grade vials are not tested as medicines.

Source: Peptide Regulation of Cell Differentiation · 2020 ↗

Evidence boundaries

The evidence is concentrated in one research network, much of it in Russian-language journals, with few independent replications and few controlled human trials. A narrative review by the originating group is not a systematic review, and seller product names may not match the exact compounds studied.

Source: Peptide Regulation of Cell Differentiation · 2020 ↗

This is not a complete list of contraindications, interactions, or adverse effects. Medicine labels apply to specific products and indications; research-use listings are not interchangeable with approved medicines.

What are people discussing?

No editorial transcript note has been reviewed for this profile yet. Below are the matching video records available for exploration; title and caption matches are not verified claims.

Watch the source discussions

0 matching video records · 0 with captions indexed.

Across the full library, 30 caption files are indexed from 20,199 inventoried videos. Most transcripts remain unreviewed. Select a thumbnail or timestamp to watch inside PepsRadar. Thumbnail images load from YouTube.

No matching video has been identified in the current snapshot.

Sources & supplier listings

Listings are grouped by the vendor’s stated identity. Blends and modified derivatives are labeled separately. Inclusion is not a quality assessment or an endorsement.

Catalog checked 2026-10-04. Seller listings retain their stated intended use. Shops covered: BioLongevity Labs, BioLongevity Supplements, American Peptides, PSPeptides. This is not a market-wide comparison. Affiliate participation does not determine evidence or editorial coverage.

Questions worth asking

• Why are 14 products covered on one page?
• What material, population, and route were actually studied?
• The evidence is concentrated in one research network, much of it in Russian-language journals, with few independent replications and few controlled human trials. A narrative review by the originating group is not a systematic review, and seller product names may not match the exact compounds studied.
• What adverse effects, uncertainty, and conflicts of interest does the original source report?

Frequently asked questions

References & editorial record

• PubMed · PMID 31808038 ↗

Source notes checked 2026-10-04. Original PepsRadar summaries. Not reviewed by a medical professional. Topic grouping is editorial navigation, not a treatment recommendation. Video notes specify which excerpts were reviewed; no full transcripts are published.

Continue exploring

Shared topics do not make these peptides interchangeable.