NAD+: Research & Studies

What is NAD+?

NAD+ is a cofactor involved in cellular redox metabolism. A human pilot measured its metabolic fate during infusion; that experiment did not test longevity, cognition, or treatment of a disease.

Biological role or research focus

Cellular metabolism and infusion research.

This was a metabolic-fate experiment, not a controlled clinical efficacy trial. It cannot establish anti-aging or cognitive benefit.

Role reference: A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD. · 2019 ↗

Names you may encounter

NAD plus · Nicotinamide adenine dinucleotide

Search terms can include brands, combinations, or historical names. They are not automatic product equivalents.

Class / identity: Redox cofactor; not a peptide
Research focus: Cellular metabolism and infusion research
Featured evidence: Human metabolic pilot study
Source check: October 4, 2026

Source: A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD. · 2019 ↗

Biology & proposed mechanism

The publication followed NAD+ and related metabolites in plasma and urine. Metabolite movement after administration does not show that intracellular function or a clinical condition improved.

Source: A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD. · 2019 ↗

Research context & identity

This profile distinguishes NAD+ from its precursors, including NR and NMN. Studies of a precursor or a different route should not be relabeled as direct NAD+ treatment evidence.

Source: A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD. · 2019 ↗

What does the evidence show?

Selected published evidence, with the population, findings, and limits kept together. These original summaries draw on publication abstracts; they are not a systematic review.

Human metabolic pilot study · 2019

Metabolic fate of intravenous NAD+

What did this publication test, and what did it find?

Population / model: Human volunteers in an intravenous-infusion pilot.
Study design: Plasma and urine metabolite measurements during a six-hour infusion period.
Main finding: The investigators did not observe an initial plasma increase during the first two hours. Urinary NAD+ and methyl-nicotinamide increased over the infusion period.
Limits & context: This was a metabolic-fate experiment, not a controlled clinical efficacy trial. It cannot establish anti-aging or cognitive benefit.

Read PubMed abstract ↗Publisher paper ↗Free full text ↗

Source: A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD. · 2019 ↗

Read the original paper for methods, adverse events, funding, and conflicts of interest. Publisher access may require a subscription.

Further reading · 4 additional publication links

Exact-name PubMed search checked 2026-10-04. These records have not been appraised. A name match can include related compounds, combinations, or other formulations; it does not establish safety or benefit.

NAD(+) Metabolism and Regulation: Lessons From Yeast. ↗
Biomolecules · 2020 Feb 19 · Journal Article, Research Support, N.I.H., Extramural, Review
Read available full text ↗

NAD(+) metabolism and its roles in cellular processes during ageing. ↗
Nature reviews. Molecular cell biology · 2021 Feb · Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review
Read available full text ↗

NAD+ and sirtuins in aging and disease. ↗
Trends in cell biology · 2014 Aug · Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review
Read available full text ↗

NAD(+) metabolism, stemness, the immune response, and cancer. ↗
Signal transduction and targeted therapy · 2021 Jan 1 · Journal Article, Research Support, Non-U.S. Gov't, Review
Read available full text ↗

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Safety & precautions

Safety & what remains unknown

An infusion’s metabolic measurements do not define a complete adverse-event profile. Route, formulation, and clinical monitoring matter.

Source: A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD. · 2019 ↗

Evidence boundaries

This was a metabolic-fate experiment, not a controlled clinical efficacy trial. It cannot establish anti-aging or cognitive benefit.

Source: A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD. · 2019 ↗

This is not a complete list of contraindications, interactions, or adverse effects. Medicine labels apply to specific products and indications; research-use listings are not interchangeable with approved medicines.

What are people discussing?

No editorial transcript note has been reviewed for this profile yet. Below are the matching video records available for exploration; title and caption matches are not verified claims.

Watch the source discussions

29 matching video records · 8 with captions indexed.

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