Peps
What is Kisspeptin-54?
Kisspeptin-54 is a reproductive-signaling peptide studied as an egg-maturation trigger during IVF. It is a distinct form from the shorter kisspeptin-10 already covered in this directory.
Biological role or research focus
Reproductive signaling and IVF research.
This was not a head-to-head comparison with a standard trigger. Clinical pregnancy is also different from a proven live-birth advantage.
Role reference: Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization. · 2014 ↗
Names you may encounter
Kisspeptin · KP-54 · Metastin
Search terms can include brands, combinations, or historical names. They are not automatic product equivalents.
- Class / identity
- KISS1-derived kisspeptin-54
- Research focus
- Reproductive signaling and IVF research
- Featured evidence
- Human dose-ranging study
- Source check
- October 4, 2026
Source: Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization. · 2014 ↗
Biology & proposed mechanism
Kisspeptin signaling stimulates the reproductive hormone pathway through its receptor and downstream GnRH/LH responses. The length and exact tested form matter when interpreting results.
Source: Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization. · 2014 ↗
Research context & identity
The featured publication concerns supervised IVF following controlled ovarian stimulation. It does not establish a general fertility supplement or interchangeable effects of all kisspeptin fragments.
Source: Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization. · 2014 ↗
What does the evidence show?
Selected published evidence, with the population, findings, and limits kept together. These original summaries draw on publication abstracts; they are not a systematic review.
Human dose-ranging study · 2014
Kisspeptin-54 triggering of egg maturation
What did this publication test, and what did it find?
- Population / model
- 53 women undergoing IVF.
- Study design
- Dose-ranging administration of kisspeptin-54 after ovarian stimulation, with egg maturation, fertilization, and pregnancy follow-up.
- Main finding
- Egg maturation was observed, and fertilization with embryo transfer occurred in 49 of 53 participants. The study reported 12 clinical pregnancies.
- Limits & context
- This was not a head-to-head comparison with a standard trigger. Clinical pregnancy is also different from a proven live-birth advantage.
Source: Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization. · 2014 ↗
Read the original paper for methods, adverse events, funding, and conflicts of interest. Publisher access may require a subscription.
Further reading · 4 additional publication links
Exact-name PubMed search checked 2026-10-04. These records have not been appraised. A name match can include related compounds, combinations, or other formulations; it does not establish safety or benefit.
GPR54 and kisspeptins. ↗
Results and problems in cell differentiation · 2008 · Journal Article, Research Support, Non-U.S. Gov't, Review
Kisspeptin-54 ameliorates chondrocyte senescence in osteoarthritis via SIRT3-mediated telomere protection and p53 acetylation inhibition. ↗
Neuropeptides · 2025 Dec · Journal Article
Kisspeptin-54 Restores Blood-Brain Barrier Integrity via GATA-4 in Ischemic Stroke. ↗
Chemical biology & drug design · 2025 Jun · Journal Article
Intranasal kisspeptin administration rapidly stimulates gonadotropin release in humans. ↗
EBioMedicine · 2025 May · Journal Article, Randomized Controlled Trial
Read available full text ↗
New editorial updates
New source discoveries
Links appear automatically. Unreviewed discoveries are not verified medical findings.
Safety & precautions
Safety & what remains unknown
Supervised IVF findings cannot establish safety or effectiveness of self-administered material, and the trial does not resolve uncommon reproductive risks.
Source: Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization. · 2014 ↗
Evidence boundaries
This was not a head-to-head comparison with a standard trigger. Clinical pregnancy is also different from a proven live-birth advantage.
Source: Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization. · 2014 ↗
This is not a complete list of contraindications, interactions, or adverse effects. Medicine labels apply to specific products and indications; research-use listings are not interchangeable with approved medicines.
What are people discussing?
No editorial transcript note has been reviewed for this profile yet. Below are the matching video records available for exploration; title and caption matches are not verified claims.
Watch the source discussions
4 matching video records · 0 with captions indexed.
Across the full library, 30 caption files are indexed from 20,199 inventoried videos. Most transcripts remain unreviewed. Select a thumbnail or timestamp to watch inside PepsRadar. Thumbnail images load from YouTube.
Biohackingturkey
The Secret Key to Testosterone: What Is Kisspeptin-10? ↗
Title match · Captions not indexed
Biohackingturkey
What is Kisspeptin? The Hormone's Functions and Effects. ↗
Title match · Captions not indexed
Dr. Trevor Bachmeyer
Kisspeptin and IVF, Fertility and TRT - Dr Trevor Bachmeyer ↗
Title match · Captions not indexed
Dr. Trevor Bachmeyer
Kisspeptin Masterclass (more than fertility) - Dr Trevor Bachmeyer ↗
Title match · Captions not indexed
Sources & supplier listings
Listings are grouped by the vendor’s stated identity. Blends and modified derivatives are labeled separately. Inclusion is not a quality assessment or an endorsement.
We have not added a supplier for this profile. Missing products and coded listings are not filled with guesses.
Catalog checked 2026-10-04. Seller listings retain their stated intended use. Shops covered: BioLongevity Labs, BioLongevity Supplements, American Peptides, PSPeptides. This is not a market-wide comparison. Affiliate participation does not determine evidence or editorial coverage.
Questions worth asking
- Is this the same profile as Kisspeptin-10?
- What material, population, and route were actually studied?
- This was not a head-to-head comparison with a standard trigger. Clinical pregnancy is also different from a proven live-birth advantage.
- What adverse effects, uncertainty, and conflicts of interest does the original source report?
Frequently asked questions
Is this the same profile as Kisspeptin-10?
No. Both belong to the kisspeptin family, but the featured trial used kisspeptin-54. Evidence should retain the tested form.
Source: Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization. · 2014 ↗
Does the publication verify a supplier’s product?
No. The tested material and a commercial listing need separate identity and batch checks. A research-use disclaimer does not establish clinical suitability.
Source: Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization. · 2014 ↗
References & editorial record
Source notes checked 2026-10-04. Original PepsRadar summaries. Not reviewed by a medical professional. Topic grouping is editorial navigation, not a treatment recommendation. Video notes specify which excerpts were reviewed; no full transcripts are published.